The results of Synbio Technologies second “Sequence of the Year” evaluation were officially announced! We are proud to reveal that the silk fibroin gene has been selected as the 2025 Sequence of the Year, recognizing its milestone achievements in AI-powered design and gene synthesis technologies.

Known as the “natural biological steel,” silk fibroin combines exceptional strength, toughness, and outstanding biocompatibility, making it one of the most promising structural proteins in nature. This sequence is characterized by ultra-long, high-density repeats, encoding complex structural information and functional potential. Detailed analysis and construction of this complete sequence provide a critical foundation for high-performance biomaterials and cutting-edge life science research.

Key Highlights of the Sequence:

AI-Powered Design and Innovation

The sequence was deeply optimized using AI, achieving intelligent construction of naturally ultra-long repetitive genes. This establishes a reliable paradigm for rational design of complex functional genes.

High Complexity Challenge

The 20 nt long repeat unit occurs 1,884 times, and the short repeat density (9 nt) reaches 95.6%. Such extreme repetitiveness poses significant challenges for synthesis accuracy and stability.

Potential Applications

This naturally structured protein exhibits excellent mechanical properties and biocompatibility. Its applications span tissue engineering and biomaterials, as well as emerging fields like flexible electronics and smart wearables, offering new avenues for protein-based material innovation.

Synbio Technologies will continue to integrate AI gene design, synthesis technology innovation, and application ecosystem development, striving to push the boundaries of biological design complexity and possibility. We look forward to collaborating with global partners to expand the frontiers of synthetic biology technologies and applications.