CpG-ODN
Home > Standard Oligo > CpG-ODN
CpG-ODN
CpG ODNs are short synthetic single-stranded DNA molecules containing unmethylated oligodeoxynucleotides (ODNs). Pre-clinical studies and trials have demonstrated that CpG ODNs can significantly improve vaccine-specific antibody responses.

CpG ODNs possess a partial or complete phosphorothioate (PS) backbone, as opposed to the natural phosphodiester (PO) backbone found in genomic bacterial DNA. Three major classes of stimulatory CpG ODNs have been identified. These classes are based on structural characteristics and activity on human peripheral blood mononuclear cells (PBMCs), in particular B cells and plasmacytoid dendritic cells (pDCs). These three classes are Class A (Type D), Class B (Type K) and Class C.

Synbio Technologies offer all these three types of CpG ODNs, each class boasts unique structural characteristics and immune effects suited for different applications.
Highlights
  • High Purity
    >95% purity
  • Low Endotoxin
    Endotoxin level <5 EU/mg
  • Various Unit Size
    Sizing from mg to g
  • Cost-Effective
    Competitive prices and Customized Synthesis
Product List

Class A CpG ODNs are characterized by a PO central CpG-containing palindromic motif and a PS-modified 3’ poly-G string. They induce high IFN-α production from pDCs but are weak stimulators of TLR9-dependent NF-κB signaling and pro-inflammatory cytokine (e.g. IL-6) production.

Class B CpG ODNs are linear and fully modified with phosphorothioates. They possess strong immunostimulatory activity on B cells but fail to activate plasmacytoid dendritic cells.

Class C CpG ODNs combine features of both class A and B, making them highly versatile as they activate both plasmacytoid dendritic cells and B cells.


Class Name Lot(#) Species Size /Tube
Class A CpG ODN 1585 SOC-A1585 Mouse 1mg
Class A CpG ODN2216 SOC-A2216 Human Preferred 1mg
Class A CpG ODN 2336 SOC-A2336 Human Preferred 1mg
Class B CpG ODN 1668 SOC-B1668 Mouse 1mg
Class B CpG ODN 1826 SOC-B1826 Mouse 1mg
Class B CpG ODN 2006/7909 SOC-B2006 Human Preferred 1mg
Class B CpG ODN 2007 SOC-B2007 Bovine/Porcine 1mg
Class B CpG ODN BW006/684 SOC-BW006 Human &Mouse 1mg
Class B CpG QDN D-SL01 SOC-BDSL01 Multispecies 1mg
Class C CpG ODN2395 SOC-C2395 Human/Mouse 1mg
Class C CpG ODN M362 SOC-CM362 Human/Mouse 1mg
Class C CpG ODN D-SL03 SOC-CDSL03 Multispecies 1mg
Deliverables
Lyophilized DNA Oligo Powder
Certificate of Analysis (COA)
Yield: 1mg
FAQs
Resources
Get in Touch with Us
Related Services
  • Address:
    9 Deer Park Dr., Suite J-25
    Monmouth Junction, NJ 08852
  • Tel: +1 732-230-3003
  • Fax: +1 609-228-5911
  • Inquiries: quote@synbio-tech.com

This website stores cookies on your computer. These cookies are used to collect information about how you interact with our website and allow us to remember you.
To find out more about the cookies we use, see our Privacy Policy.

Accept