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CpG-ODN

CpG ODNs are short synthetic single-stranded DNA molecules containing unmethylated oligodeoxynucleotides (ODNs). Pre-clinical studies and trials have demonstrated that CpG ODNs can significantly improve vaccine-specific antibody responses.

CpG ODNs possess a partial or complete phosphorothioate (PS) backbone, as opposed to the natural phosphodiester (PO) backbone found in genomic bacterial DNA. Three major classes of stimulatory CpG ODNs have been identified. These classes are based on structural characteristics and activity on human peripheral blood mononuclear cells (PBMCs), in particular B cells and plasmacytoid dendritic cells (pDCs). These three classes are Class A (Type D), Class B (Type K) and Class C.

Synbio Technologies offer all these three types of CpG ODNs, each class boasts unique structural characteristics and immune effects suited for different applications.

Highlights

High Purity

＞95% purity
Low Endotoxin

Endotoxin level <5 EU/mg
Various Unit Size

Sizing from mg to g
Cost-Effective

Competitive prices and Customized Synthesis

Product List

Class A CpG ODNs are characterized by a PO central CpG-containing palindromic motif and a PS-modified 3’ poly-G string. They induce high IFN-α production from pDCs but are weak stimulators of TLR9-dependent NF-κB signaling and pro-inflammatory cytokine (e.g. IL-6) production.

Class B CpG ODNs are linear and fully modified with phosphorothioates. They possess strong immunostimulatory activity on B cells but fail to activate plasmacytoid dendritic cells.

Class C CpG ODNs combine features of both class A and B, making them highly versatile as they activate both plasmacytoid dendritic cells and B cells.

Class	Name	Lot(#)	Species	Size /Tube
Class A	CpG ODN 1585	SOC-A1585	Mouse	1mg
Class A	CpG ODN2216	SOC-A2216	Human Preferred	1mg
Class A	CpG ODN 2336	SOC-A2336	Human Preferred	1mg
Class B	CpG ODN 1668	SOC-B1668	Mouse	1mg
Class B	CpG ODN 1826	SOC-B1826	Mouse	1mg
Class B	CpG ODN 2006/7909	SOC-B2006	Human Preferred	1mg
Class B	CpG ODN 2007	SOC-B2007	Bovine/Porcine	1mg
Class B	CpG ODN BW006/684	SOC-BW006	Human &Mouse	1mg
Class B	CpG QDN D-SL01	SOC-BDSL01	Multispecies	1mg
Class C	CpG ODN2395	SOC-C2395	Human/Mouse	1mg
Class C	CpG ODN M362	SOC-CM362	Human/Mouse	1mg
Class C	CpG ODN D-SL03	SOC-CDSL03	Multispecies	1mg

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