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siRNA/miRNA Synthesis

RNA interference (RNAi) is a powerful gene silencing tool, crucial for biological and therapeutic research, especially in targeting undruggable diseases like cancer. siRNA binds to target mRNA in the RISC complex to inhibit its function, while miRNAs regulate mRNA degradation or translation, with dysregulation linked to cancer.

Synbio Technologies offers highly customized siRNA and miRNA synthesis services, ensuring high-quality products through expert synthesis techniques and rigorous quality controls. In addition, Synbio Technologies provides various chemically modified siRNAs for enhanced stability and efficacy, as well as various miRNA products, including mimics, inhibitors, and controls, to support diverse research needs.

Highlights

Provide Diversified siRNA & miRNA Products
Expert Technical Team to Provide Support
Strictly Confidential Project Details
Strict Quality Control to Avoid Contamination

Service Details

Products name	Yield	Purification	Turnaround Times	Price
siRNA NC FAM	2.5 nmol	HPLC/OPC	6-15 BD	Starting from $56
siRNA NC	2.5 nmol
siRNA	Starting from 2.5 nmol
Modified or fluorescence labeled siRNA (2-OMe, Thiol, Chol, Biotin, FAM, Cy5, Cy3, etc)	Quote		Quote

* For more information please contact us at quote@synbio-tech.com.

Synbio Technologies also provides a guaranteed siRNA service. The three/four designed and delivered siRNA ensure at least one siRNA can effectively inhibit the expression of the target gene. The resulting inhibition efficiency will be at least 70% (The transfection efficiency will be at least 90%).

Products		Purification	Turnaround Times	Price
3 siRNAs	5 nmol	HPLC/OPC	6-9 BD	$249
siRNA NC FAM	2.5 nmol
siRNA NC	2.5 nmol
Positive siRNA control	2.5 nmol
Transfection reagents	100 μL

Products		Purification	Turnaround Times	Price
4 siRNAs	5 nmol	HPLC/OPC	6-9 BD	$299
siRNA NC FAM	2.5 nmol
siRNA NC	2.5 nmol
Positive siRNA control	2.5 nmol
Transfection reagents	100 μL

* For more information please contact us at quote@synbio-tech.com.

Products	Yield	Purification	Turnaround Times	Price
miRNA mimics NC FAM	2.5 nmol	HPLC/OPC	3-5 BD	Starting from $56
miRNA mimics NC	2.5 nmol
miRNA mimics	5 nmol
miRNA inhibitors NC FAM	2.5 nmol
miRNA inhibitors NC	2.5 nmol
miRNA inhibitor	5 nmol
miRNA agomirs	2.5 nmol
miRNA antagomirs	2.5 nmol

* For more information please contact us at quote@synbio-tech.com.

QUOTE

Deliverables

Lyophilized RNA

Certificate of Analysis (COA)

QC Report (MS/HPLC)

FAQs

How to choose a suitable siRNA sequence?

Specificity: Ensure that the siRNA sequence specifically targets the target gene to avoid off-target effects.

Effectiveness: Screen siRNA sequences with high silencing efficiency.

Stability: Optimize the siRNA sequence to improve its stability and effectiveness in the cell.

How to detect the effect of RNAi?

qPCR: Quantitatively detect changes in mRNA levels of target genes.

Western Blot: Detect the expression level of the protein encoded by the target gene.

Fluorescence Microscopy: Observe the distribution and expression of siRNA or shRNA in cells by fluorescent labeling.

How do I store RNA oligos?

RNA oligos should be stored at -20°C or lower in RNase-free water or specialized RNA storage solutions to prevent degradation. Avoid repeated freeze-thaw cycles during storage to maintain their integrity.

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