General Introduction of Immune Repertoire Sequencing
Immune Repertoire refers to the set of all functionally diversified B cells and T cells in a person's circulatory system. Immune repertoire sequencing (Immuno-Seq) targets T/B lymphocytes and utilizes the 5’ Rapid Amplification of cDNA Ends (RACE) Technology. The 5’ RACE technology amplifies complementarity-determining regions (CDRs) of B cell receptors (BCRs) or T cell receptors (TCRs). The CDRs are targeted because they control the diversity of the corresponding BCRs and TCRs. Combined with high-throughput sequencing technology, the Immuno-Seq provides a comprehensive evaluation of the immune system diversity.
Synbio Technologies provides a complete antibody repertoire sequencing services, including immune repertoire sequencing and antibody CDR region sequencing. Our Immuno-Seq System is designed to assist researchers in the observation and analysis of both T and B cells; the specificity of our technology enables it to be applied to disease surveillance,
antibody production, vaccine research, health examination and other related areas.
Highlights
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- Robust RACE Technology and Specially Optimized PCR Amplification Systems
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- Diversified NGS Analysis Platform
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- Optimal Success Rates and Fast Turnaround Time
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- Complete and Advanced Bioinformatic Analysis
Service Details
* For Immuno-Seq service: customers will need to submit one of the following: 1-2ml peripheral blood, splenocyte, selected immune cells, or extracted high quality RNA.
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Service
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Deliverables
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Turnaround Time
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Price
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Immune Repertoire Sequencing
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· NGS sequencing data
· Bioinformatics analysis report
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6-8 Weeks
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Quote
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Workflow
FAQs
1. Examine health status through analysis of the immune/antibody repertoire diversity
2. Trace the development of antigen-specific antibodies and contribute to the research being conducted on humanized antibodies
3. Evaluate vaccine effectiveness
5' RACE only requires RNA samples to be provided, whereas multiplex PCR requires both DNA and RNA samples.
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