General Introduction of Long RNA Synthesis
Long non-coding RNA (lncRNAs) are RNA molecules longer than 200 nucleotides that do not encode proteins. They are vital in regulatory processes like X-chromosome silencing, genomic imprinting, chromatin modification, transcriptional activation, transcriptional interference, and intranuclear transport.
Synbio Technologies utilizes its advanced Syno R synthesis platform and extensive expertise to synthesize long chain RNAs of various lengths, specifications, and modifications while ensuring 100% accurate target RNA sequences. In addition, Synbio Technologies also offers a wide range of small molecule coupling services including GalNAc, peptide oligonucleotides, and chelating agents such as NOTA, DOTA, MAG, and DTPA to meet our customers’ various research needs.
Highlights
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- Long RNA Oligos Up to 110 nt
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- Rnase-free HPLC Purified
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- Multiple Modifications Available
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- Large-scale Yields from mg to gram
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- Highly Customized
Service Details
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Product
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Length
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Order Size
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Modifications
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Purification
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Large-scale RNA Synthesis
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5-110 nt
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50mg to several grams
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PS, PO or PS/PO skeletons, chimeric oligonucleotides mixed with 2′-OMe, 2′-F-RNA, MOE, LNA or DNA
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HPLC
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Deliverables
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Lyophilized RNA
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Certificate of Analysis (COA)
FAQs
When choosing an RNA polymerase, select the appropriate enzyme according to the promoter sequence on the DNA template, e.g. T7 RNA polymerase is suitable for T7 promoter, T3 RNA polymerase is suitable for T3 promoter, and SP6 RNA polymerase is suitable for SP6 promoter.
The template for RNA synthesis is a strand of DNA that is transcribed by T7, T3, or SP6 RNA phage polymerase in the presence of ribonucleoside triphosphates (rNTPs). This polymerase moves along the template strand, using base pairing with the DNA to create a complementary RNA strand, substituting uracil for thymine.
RNA oligos should be stored at -20°C or lower in RNase-free water or specialized RNA storage solutions to prevent degradation. Avoid repeated freeze-thaw cycles during storage to maintain their integrity.
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