AI is reshaping protein research at several stages, from predicting protein structures and functions to designing novel proteins from scratch, unlocking the molecular mysteries of life.

Protein structure prediction: AI predicts 3D protein structures via multiple sequence comparison information. Representative models include AlphaFold and RoseTTAFold.

Protein function prediction: AI can also help infer what a protein may do by analyzing sequence information, structural characteristics, protein interactions, and existing functional annotations. DeepGO and DeepGO-SE are advanced models for protein function prediction.

Protein optimization and de novo design: Existing proteins can be optimized for properties such as stability, affinity, and catalytic activity, while AI can create entirely new sequences or structures for specific objectives. Tools include ProteinMPNN, RFdiffusion, ProGen, and AlphaProteo.

AI is providing researchers with new ways to explore protein sequences and identify promising proteins before experimental testing.

How can AI-driven protein design be turned into functional proteins? It involves six steps:

Validating and transforming AI proteins involves a complex wet-lab verification process. Synbio Technologies provides researchers with a one-stop solution. You only need to provide the protein sequence, and we handle all the details.

DNA Level

• Custom DNA Oligos
• Diagnostic Probes & Oligos
• Gene Synthesis
• ssDNA synthesis
• Antibody Gene Synthesis
• Variant Libraries
• Standard Genome KO Libraries
• sgRNA Customized Design, etc.

RNA Level

• Custom RNA Oligos
• RNA Modification
• siRNA /miRNA Synthesis
• Long RNA Synthesis
• sgRNA Synthesis
• In Vitro Transcription

Protein Level

• Codon Optimization
• Protein Expression
• Hybridoma Antibody Sequencing
• Immune Repertoire Sequencing
• Recombinant Ab Production
• Monoclonal Antibody Preparation
• Polyclonal Antibody Preparation, etc.

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AI protein design is expanding across drug, antibody, enzyme, and synthetic biology.

• Drug Discovery: Accelerate target identification, binding-site analysis, and protein-based drug design.

• Antibody Discovery: Support antigen-antibody modeling and antibody development.

• Enzyme and Protein Engineering: Develop proteins and enzymes with tailored functional properties.

• Synthetic Biology: Apply protein design to agriculture, food, and industrial biotechnology.

Integrated Workflow

Connect DNA synthesis, RNA technologies, protein expression, and antibody services within a coordinated project workflow.

Multiple Expression Systems

Access bacterial, yeast, insect, and mammalian expression systems, allowing expression to be matched to different protein characteristics and research requirements.

Sequence-to-Function Support

Start with a designed protein sequence and finish with codon optimization, gene synthesis, expression, purification, characterization, and functional validation.

Customized Project Design

Projects can be tailored according to protein type, research objectives, and delivery requirements, suitable for different scales of protein production.