DNA sequencing has been vital to the development of synthetic biology in many ways. Sequencing enables researchers to determine the DNA sequence in just about any gene, and enables the construction of vast databases that can hold entire genomes. Genome databases are an important resource for downstream synthetic biology applications such as protein expression, directed evolution, and metabolic engineering. In addition, the low cost of DNA sequencing enables more efficient quality control of large DNA constructs, a key step in gene synthesis.

Reductions in the production costs of genes and their key raw materials, oligos, are driving demand for synthetic biology products. Gene synthesis is key to many synthetic biology applications, and their availability at low cost increases the number of gene synthesis applications and customers, driving sales up.

The growing proteomics market is driving demand for more efficient protein expression in novel host systems. This in turn is driving the demand for synthetic genes that have been optimized for heterologous gene expression. Such optimized genes allow for expressing the desired protein product more efficiently, since they can be tailored to the intended host cell system. Gene synthesis will penetrate into the genetic engineering market among pharmaceutical and biotech companies developing new products. Gene synthesis provides a high level of flexibility to the customer and, as its cost decreases, its services are rapidly permeating the classical genetic engineering market to become standard tools among end users.

Synthetic biology applications driven by gene synthesis technology:

• HGP-Write
  The Human Genome Project – Write, formally announced on 2 June 2016, is a ten-year extension of the Human Genome Project, to synthesize the human genome. The human genome consists of three billion DNA nucleotides, which were described in the Human Genome Project – Read program, completed in 2003. With the advancement of gene synthesis technology, the time and cost of gene synthesis is approaching Moors’ Law. Many researchers expect that the ability to synthesize large portions of the human genome could lead to many scientific and medical advances.
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• Antibody Library
  The traditional humanized antibody library refers to a group of re-expressed antibodies which have been transformed by gene cloning and DNA recombination technology based on mouse monoclonal antibody. Synbio Technologies designed and developed unique antibody humanization strategies based on advanced concepts and technologies in synthetic biology. This, combined with the integration of efficient phage display and cell surface display technology, have allowed Synbio Tech to easily provide fast and efficient humanized antibody services.
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• DNA storage
  DNA storage (using DNA as a data carrier) technology is a relatively new discovery that may have monumental implications on the future of bioinformatics and data science. Text, images, audio, and video documents could be transformed into “A, T, C, G” format and stored in artificial synthesized DNA. Scientists from Synbio Technologies have mastered next generation gene synthesis technology which greatly reduces the manufacturing cost of DNA synthesis. Combined with our patented DNA Studio^TM software, DNA storage is closer than ever to spearheading the next generation of storage technology.
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