Antibody engineering research relies on antibody protein expression. The optimization of antibody sequences and vector construction affect whether the protein can be expressed efficiently. The construction of the expression vector is a very important basis for recombinant antibody proteins. Synbio Technologies‘s self-developed NG™ codon optimization technology and Syno® gene technologies can synthesize antibody heavy chain/light chain sequences and clone them into Synbio Technologies’s ready-to-use or customized vector for free, ensuring high-efficiency expression and assisting antibody engineering research.

Competitive Advantages

  • One-Stop Service: Synbio Technologies provides one-stop solutions from gene synthesis, plasmid preparation, to recombinant antibody.
  • Sequence Guaranteed: Sanger sequencing ensures 100% sequence accuracy.
  • NGTM Codon Optimization: Significantly increase expression level in most host cells.
  • Free Vector Construction: Synbio Technologies can provide a series of vectors or customers can provide their own preferred construction vectors.
  • Highly Customized: Gene synthesis of multiple types of antibodies: anti-viral monoclonal antibodies, bispecific recombinant antibodies, human monoclonal antibodies engineered with anti-cancer Fc, etc.

Antibody Gene Synthesis Process

* Synbio Technologies also provides above one-stop services from hybridoma sequencing to recombinant antibody.

Service Specifications

Gene Length Price Turnaround Time
(business day)
Additional Value Deliverables
≤500bp
(Heavy and light chain variable region sequences)
$99/ construct
(bulk price available)
10
  • Free codon optimization
  • Free in-house vectors with pre-synthesized constant regions for cloning and expression
  • Free custom vector deposit
  • Free sequence verification
  • Antibody expression service available at different scales
  • Antibody gene fragment synthesis available, starting at $27 per gene fragment
  • 100 μg endo-free plasmid
  • Sequence verification result
  • Certificate of analysis

Vector Types

Vector Name Vector Map Description
pAb20-hCK Vector Type: Human Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type: hCK
pAb20-hCL-1 Vector Type: Human Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type: hCL
pAb20-hCHIgG1 Vector Type: Human Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type: hCH IgG1
pAb20-hCL-2 Vector Type: Human Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type: hCL
pAb20-hCHIgG2 Vector Type: Human Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type: hCH IgG2
pAb20-hCHIgG3 Vector Type: Human Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type: hCH IgG3
pAb20-hCHIgG4 Vector Type: Human Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type: hCH IgG4
pAb20-hCHIgM Vector Type: Human Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type: hCH IgGM

Vector Name Vector Map Description
pAb20-mCK Vector Type: Mouse Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type: mCK
pAb20-mCL-1 Vector Type: Mouse Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type: mCL
pAb20-mCL-2 Vector Type: Mouse Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type: mCL
pAb20-mCHIgG1 Vector Type: Mouse Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type: mCH IgG1
pAb20-mCHIgG2a Vector Type: Mouse Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type:mCH IgG2a
pAb20-mCHIgG2b Vector Type: Mouse Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type:mCH IgG2b
pAb20-mCHIgG3 Vector Type: Mouse Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type:mCH IgG3
pAb20-mCHIgM Vector Type: Mouse Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type:mCHIgM

 

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