Harness the power of human genetics with our advanced Antibody Gene Synthesis services. Utilizing our proprietary NG codon optimization technology and Syno gene technologies, we specialize in synthesizing antibody heavy chain/light chain sequences, ensuring high-efficiency expression to bolster antibody engineering research.

Our NG codon optimization technology boosts protein expression by optimizing codon usage for efficient transcription and translation. Syno gene technology, on the other hand, allows for the synthesis of high-fidelity gene fragments to ensure the correct sequence of the target antibody genes.

The optimized sequences are then cloned into Synbio Technologies’ ready-to-use, or customized, vectors while ensuring the highest levels of efficiency in antibody expression. This highly efficient process streamlines antibody engineering research and paves the way for the development of new and effective therapeutic interventions.

Antibody gene synthesis

Maximize Your Antibody Production with our
Advanced Technologies

  • One-Stop Service: Synbio Technologies provides one-stop solutions from gene synthesis, plasmid preparation, to recombinant antibody.
  • Sequence Guaranteed: Sanger sequencing ensures 100% sequence accuracy.
  • NG Codon Optimization: Significantly increase expression level in most host cells.
  • Free Vector Construction: Synbio Technologies can provide a series of vectors or customers can provide their own preferred construction vectors.
  • Highly Customized: Gene synthesis of multiple types of antibodies: anti-viral monoclonal antibodies, bispecific recombinant antibodies, human monoclonal antibodies engineered with anti-cancer Fc, etc.

Antibody Gene Synthesis Process

Antibody gene synthesis

* Synbio Technologies also provides above one-stop services from hybridoma sequencing to recombinant antibodies.

Service Specifications

Gene Length Price Turnaround Time
(business day)
Additional Value Deliverables
≤500bp
(Heavy and light chain variable region sequences)
$99/ construct
(bulk price available)
10
  • Free codon optimization
  • Free in-house vectors with pre-synthesized constant regions for cloning and expression
  • Free custom vector deposit
  • Free sequence verification
  • Antibody expression service available at different scales
  • Antibody gene fragment synthesis available, starting at $27 per gene fragment
  • 100 μg endo-free plasmid
  • Sequence verification result
  • Certificate of analysis

Vector Types

Vector Name Vector Map Description
pAb20-hCK Vector Type: Human Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type: hCK
pAb20-hCL-1 Vector Type: Human Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type: hCL
pAb20-hCHIgG1 Vector Type: Human Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type: hCH IgG1
pAb20-hCL-2 Vector Type: Human Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type: hCL
pAb20-hCHIgG2 Vector Type: Human Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type: hCH IgG2
pAb20-hCHIgG3 Vector Type: Human Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type: hCH IgG3
pAb20-hCHIgG4 Vector Type: Human Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type: hCH IgG4
pAb20-hCHIgM Vector Type: Human Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type: hCH IgGM
Vector Name Vector Map Description
pAb20-mCK Vector Type: Mouse Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type: mCK
pAb20-mCL-1 Vector Type: Mouse Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type: mCL
pAb20-mCL-2 Vector Type: Mouse Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type: mCL
pAb20-mCHIgG1 Vector Type: Mouse Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type: mCH IgG1
pAb20-mCHIgG2a Vector Type: Mouse Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type:mCH IgG2a
pAb20-mCHIgG2b Vector Type: Mouse Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type:mCH IgG2b
pAb20-mCHIgG3 Vector Type: Mouse Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type:mCH IgG3
pAb20-mCHIgM Vector Type: Mouse Antibody Expression Vector
Promoter: CMV Promoter
Vector Resistance: Ampicillin
Fc Type:mCHIgM

 

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