Advances in DNA synthesis technologies have made it possible to synthesize and construct new metabolic pathways and chromosomes elements while increasing our understanding to system horizontal phenomena. According to underlying design principles, the synthesis of ultra-long DNA fragments altered the genetic structure of pathways and chromosomes. In 2016, 25 scientists from Harvard University, MIT, New York University, and other universities announced that they would raise $100 million to launch Genome Project-Write Project (GP-write). This project includes microbial genome and human genome synthesis, hoping to find a better understanding and application for life system through synthetic biology, gene editing, and other technologies. In May 2017, Synbio Technologies was invited to attend the Genome Project-Write Meeting (GP-Write) held at the New York Genome Center. Ultra-long genome synthesis is supposed to promote biological gene transformation and support the research and development of bio-based therapies, vaccines, materials, energy, nutrients, and disease vectors.