Rely on Synbio Technologies’ Syno Human Genome CRISPR Knockout Libraries for precise, efficient gene editing. Our libraries, outperforming traditional methods like ZFN and TALEN, are essential for researchers in areas such as genetic disorder studies, oncology research, agricultural genetic engineering, and the development of novel therapeutics.

Our libraries consist of three specialized sub-libraries.

  • Sub-library A, targeting 18,913 protein-coding genes, is ideal for high-quality screening with minimal sgRNA coverage.
  • Sub-library B expands this with 18,334 genes, providing additional sgRNAs for more comprehensive coverage.
  • Sub-library C, our compact yet powerful library, targets 37,522 gene-specific and 200 non-targeted sgRNAs across 18,761 genes, making it particularly effective for intricate CRISPR screenings in cancer research and complex genetic studies.

With Synbio Technologies’ Syno Human Genome CRISPR Knockout Libraries, you can expect reduced research costs, faster project timelines, and superior results. Our libraries are specifically designed to advance research in critical areas like disease pathogenesis, drug resistance mechanisms, and genetic trait analysis in crops, paving the way for significant scientific breakthroughs.

Human Genome CRISPR Knockout / Activation Libraries

Catalog Product Name Sequence Details Vector Details Specifications
STCRI211101 Syno Human Genome CRISPR Knockout Libraries Sub library A
18,913 genes are targeted, 74,552 sgRNA sequences and 435 control (non-targeted) sgRNA sequences are designed, with a total of 74,987 sgRNA sequences.
pLentiCRISPR v2 (with Puro mark) 200μg
pLentiGuide (with Puro mark)
pLentiGuide (with Puro-GFP mark)
STCRI211102 Sub Library B
18,334 genes are targeted, 71,048 sgRNA sequences and 435 control (non-targeted) sgRNA sequences are designed, with a total of 71,483 sgRNA sequences.
pLentiCRISPR v2 (with Puro mark) 200μg
pLentiGuide (with Puro mark)
pLentiGuide (with Puro-GFP mark)
STCRI211103 Sub Library C
18,761 genes are targeted, 37,522 sgRNA sequences and 200 control (non-targeted) sgRNA sequences are designed, with a total of 37,722 sgRNA sequences.
pLentiCRISPR v2 (with Puro mark) 200μg
pLentiGuide (with Puro mark)
pLentiGuide (with Puro-GFP mark)
STCRI233301 Syno Human Genome CRISPR Activation Libraries Sub library A
18,885 genes are targeted, 56,266 sgRNA sequences and 496 control (non-targeted) sgRNA sequences are designed, sgRNA size 20 bp.
Syn-pXPR_502 200μg
STCRI233302 Sub library B
18,843 genes are targeted, 55,980 sgRNA sequences and 496 control (non-targeted) sgRNA sequences are designed, sgRNA size 20 bp.
Syn-pXPR_502 200μg

Reasons to Work with Us

By employing advanced sgRNA design models and deep learning algorithms, we meticulously craft sgRNA sequences that ensure high target activity and a minimal off-target rate, reflecting our commitment to precision and efficacy in design.

sgRNA Library Design

We provide customized services such as NGS verification, virus packaging, and bioinformatics analysis.

Our optimized LentiCRISPRv2 vector, equipped with a Puro drug screening feature, enhances lentivirus packaging and boosts transfection efficiency, offering a more effective and streamlined approach to gene editing.

Our high editing efficiency CRISPR library streamlines subsequent screening processes, significantly lowering research costs and providing cost-effective solutions without compromising quality.

Our strict quality control ensures exceptional performance of the constructed library, with coverage exceeding 99.9% and maintaining uniformity below 10%, demonstrating our commitment to delivering unparalleled precision and reliability in our products.