Human Pathway-focused sgRNA libraries
By leveraging the power of CRISPR/Cas9 technology, our advanced gene screening program rapidly identifies genes related to a phenotype or screens new drug targets in order to better understand metabolic pathways and facilitate breakthroughs in disease treatment. Synbio Technologies has taken CRISPR gene editing technology to the next level with our library construction service, launching more than 100 sgRNA libraries focused on human pathways at various stages of research. This highly efficient toolset allows researchers to easily target and screen specific molecular pathways for further investigation.
Synbio Technologies offers an unparalleled library of sgRNA sequences, specifically designed for human pathways with advanced targeting algorithms to minimize off-targeting. Customers are provided with over 100 options along with 200+ custom delivery experiences that give confidence in the product quality – a guarantee backed by 26+ publications boasting impressive impact factors. Our human pathway-focused sgRNA library services are an innovative solution for drug discovery researchers looking to accelerate their research and development processes. Our libraries are carefully designed and optimized to target key genes involved in human disease, with a high level of specificity and efficiency. With our sgRNA libraries, researchers can achieve highly effective gene editing and screening, enabling the identification of new drug targets and the development of more effective therapies. Our libraries are easy to use and compatible with a wide range of applications, making them a versatile tool for any drug discovery project. We are committed to providing the highest quality services and support to our customers, with fast turnaround times and personalized assistance. With our human-focused sgRNA library services, drug discovery researchers can stay at the forefront of their field and make significant strides in the development of new treatments for human diseases.
Pathway-focused sgRNA plasmid library deliverables
Mixing pool
(finished product *customizable)
An array of sgRNAs from the gene library can be quickly and conveniently utilized for transfection or lentivirus packaging, all stored in one tube.
Array
(*customizable)
Experience the utmost convenience and flexibility with our array plate – providing a single well for each target gene.
Human Pathway-focused sgRNA libraries
* Lentisyn001 Vector
Metabolic process | Catalog | Library name | Gene numbers |
Replication and repair | SHPF231001 | Base excision repair | 33 |
SHPF231002 | DNA replication | 36 | |
SHPF231003 | Fanconi anemia pathway | 54 | |
SHPF231004 | Homologous recombination | 41 | |
SHPF231005 | Mismatch repair | 23 | |
SHPF231006 | Non-homologous end-joining | 13 | |
SHPF231007 | Nucleotide excision repair | 47 | |
Transcription | SHPF232001 | Basal transcription factors | 45 |
SHPF232002 | RNA polymerase | 34 | |
SHPF232003 | Spliceosome | 154 | |
Translation | SHPF233001 | Aminoacyl-tRNA biosynthesis | 66 |
SHPF233002 | mRNA surveillance pathway | 97 | |
SHPF233003 | Nucleocytoplasmic pathway | 108 | |
SHPF233004 | Ribosome biogenesis in eukaryotes | 118 | |
SHPF233005 | Ribosome | 167 | |
Transport and catabolism | SHPF234001 | Autophagy | 141 |
SHPF234002 | Endocytosis | 251 | |
SHPF234003 | Lysosome | 132 | |
SHPF234004 | Mitophagy | 72 | |
SHPF234005 | Peroxisome | 82 | |
SHPF234006 | Phagosome | 152 | |
Cellular community | SHPF235001 | Adherens junction | 71 |
SHPF235002 | Focal adhesion | 201 | |
SHPF235003 | Gap junction | 88 | |
SHPF235004 | Signaling pathways regulating pluripotency of stem cells | 143 | |
SHPF235005 | Tight junction | 169 | |
Cell death | SHPF236001 | Apoptosis | 136 |
SHPF236002 | Cell cycle | 127 | |
SHPF236003 | Cellular senescence | 156 | |
SHPF236004 | Ferroptosis | 41 | |
SHPF236005 | Necroptosis | 159 | |
SHPF236006 | Oocyte meiosis | 131 | |
SHPF236007 | p53 signaling pathway | 73 | |
Cell motility | SHPF236101 | Regulation of actin cytoskeleton | 229 |
Folding, sorting and degradation | SHPF237001 | Proteasome | 46 |
SHPF237002 | Protein export | 23 | |
SHPF237003 | Protein processing in endoplasmic reticulum | 171 | |
SHPF237004 | RNA degradation | 79 | |
SHPF237005 | SNARE interactions in vesicular transport | 33 | |
SHPF237006 | Sulfur relay system | 8 | |
SHPF237007 | Ubiquitin mediated proteolysis | 142 | |
Development and regeneration | SHPF238001 | Axon guidance | 182 |
SHPF238002 | Osteoclast differentiation | 128 | |
Signal transduction | SHPF239001 | AMPK signaling pathway | 121 |
SHPF239002 | Apelin signaling pathway | 139 | |
SHPF239003 | Calcium signaling pathway | 240 | |
SHPF239004 | cAMP signaling pathway | 225 | |
SHPF239005 | cGMP-PKG signaling pathway | 167 | |
SHPF239006 | ErbB signaling pathway | 85 | |
SHPF239007 | FoxO signaling pathway | 131 | |
SHPF239008 | Hedgehog signaling pathway | 56 | |
SHPF239009 | HIF-1 signaling pathway | 109 | |
SHPF239010 | Hippo signaling pathway | 157 | |
SHPF239011 | JAK-STAT signaling pathway | 166 | |
SHPF239012 | MAPK signaling pathway | 294 | |
SHPF239013 | mTOR signaling pathway | 156 | |
SHPF239014 | NF-kappa B signaling pathway | 104 | |
SHPF239015 | Notch signaling pathway | 59 | |
SHPF239016 | Phosphatidylinositol signaling system | 97 | |
SHPF239017 | Phospholipase D signaling pathway | 148 | |
SHPF239018 | PI3K-Akt signaling pathway | 354 | |
SHPF239019 | Rap1 signaling pathway | 210 | |
SHPF239020 | Ras signaling pathway | 236 | |
SHPF239021 | Sphingolipid signaling pathway | 119 | |
SHPF239022 | TGF-beta signaling pathway | 95 | |
SHPF239023 | TNF signaling pathway | 114 | |
SHPF239024 | VEGF signaling pathway | 59 | |
SHPF239025 | Wnt signaling pathway | 170 | |
Signaling molecules and interaction | SHPF231011 | Cell adhesion molecules | 157 |
SHPF231012 | Cytokine-cytokine receptor interaction | 295 | |
SHPF231013 | ECM-receptor interaction | 88 | |
SHPF231014 | Neuroactive ligand-receptor interaction | 367 | |
SHPF231015 | Viral protein interaction with cytokine and cytokine receptor | 100 | |
Circulatory system | SHPF231111 | Adrenergic signaling in cardiomyocytes | 154 |
SHPF231112 | Cardiac muscle contraction | 87 | |
SHPF231113 | Vascular smooth muscle contraction | 134 | |
Immune system | SHPF231211 | Antigen processing and presentation | 78 |
SHPF231212 | B cell receptor signaling pathway | 82 | |
SHPF231213 | Chenokine signaling pathway | 192 | |
SHPF231214 | Complement and coagulation cascades | 86 | |
SHPF231215 | C-type lectin receptor signaling pathway | 104 | |
SHPF231216 | Cytosolic DNA-sensing pathway | 66 | |
SHPF231217 | Fc epsilon RI signaling pathway | 68 | |
SHPF231218 | Fc ganna R-mediated phagocytosis | 97 | |
SHPF231219 | Hematopoietic cell lineage | 99 | |
SHPF231220 | IL-17 signaling pathway | 94 | |
SHPF231221 | Intestinal immune network for IgA production | 49 | |
SHPF231222 | Leukocyte transendothelial migration | 114 | |
SHPF231223 | Natural killer cell mediated cytotoxicity | 132 | |
SHPF231224 | Neutrophil extracellular trap formation | 190 | |
SHPF231225 | NOD-like receptor signaling pathway | 186 | |
SHPF231226 | Platelet activation | 124 | |
SHPF231227 | RIG-I-like receptor signaling pathway | 71 | |
SHPF231228 | T cell receptor signaling pathway | 104 | |
SHPF231229 | Th1 and Th2 cell differntiation | 92 | |
SHPF231230 | Th17 cell differentiation | 108 | |
SHPF231231 | Toll-like receptor signaling pathway | 104 | |
Others | SHPF231311 | ABC transporter pathway | 100 |
SHPF231312 | Acute myeloid leukemia pathway | 45 | |
SHPF231313 | Adipogenesis pathway | 126 | |
SHPF231314 | Adult stem cell pathway | 58 | |
SHPF231315 | Angiogenesis pathway | 92 | |
SHPF231316 | Apoptosis pathway | 68 | |
SHPF231317 | cAMP&Ca pathway | 91 | |
SHPF231318 | Cell cycle pathway | 84 | |
SHPF231319 | Chemokine pathway | 134 | |
SHPF231320 | Drug Resistance pathway | 348 | |
SHPF231321 | ES differentiation pathway | 334 | |
SHPF231322 | GPCR pathway | 280 | |
SHPF231323 | Hormone activity pathway | 108 | |
SHPF231324 | Ion channel pathway | 67 | |
SHPF231325 | P450 pathway | 57 | |
SHPF231326 | Tumor metastasis pathway | 60 | |
SHPF231327 | Tumor suppressor pathway | 720 | |
SHPF231328 | Neelamegham human glycogene pathway | 347 | |
SHPF231329 | Human mTORC1 Focused pathway | 713 | |
SHPF231330 | Pan druggable library | 75 |