CpG-oligodeoxynucleotides (CpG-ODN) are potent immune stimuli being developed for use as adjuvants in different species. In this study, using a cell-based activation assay, researchers developed a type of CpG-ODN containing a GACGTT or AACGTT motif in 12 phosphorothioate-modified deoxynucleotides with potent stimulatory activity for rabbit TLR9. The results of this study suggest that both the choice of CpG-motif and its length are important factors for CpG-ODN to effectively activate rabbit TLR9 mediated immune responses.
Different types of CpG ODNs have different structural characteristics and immune effects. They are generally divided into three types: Class A, Class B, and Class C. Synbio Technologies can provide these three types of CpG ODNs products, as well as synthesize the CpG sequences that you provide.